Visual Assembler
You can use Visual Mode to assemble code using A.
For example let's replace the push by a jmp:

Notice the preview of the disassembly and arrows:

You need to open the file in writing mode (r2 -w or oo+) in order to patch the file.
You can also use the cache mode: e io.cache = true and wc?.
Remember that patching files in debug mode only patch the memory not the file.